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KMID : 0978920070080020249
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Korean Journal of Clinical Geriatrics
2007 Volume.8 No. 2 p.249 ~ p.255
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Insulin-like Growth Factor 1 (IGF-1) and Cognitive Function in the Elderly
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Lee Sang-Hyun
Cho Kyung-Hee
Pak Serng-Bai
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Abstract
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Background: Cognitive function and insulin-like factor 1 (IGF-1) is known to decline with aging. The purpose of this study was to investigate the relationship between IGF-1 and cognitive function.
Methods: This study population consisted of a sample of 185 healthy participants from a health promotion center, aged 60 or older. They were evaluated by IGF-1, short form of the Samsung Dementia Questionnaire (S-SDQ), Korean Dementia Screening Questionnaire (KDSQ), and Korean Mini Mental State Examination (K-MMSE).
Results: The subjects’ mean age was 65.7 years and their mean IGF-1 level was 222.5 ng/ml. We found that IGF-1 was correlated with their body weight, hemoglobin and serum cholesterol, whereas IGF-1 wast not associated with cognitive function in the univariate analysis. Through multiple regression analysis, IGF-1 levels seemed to be associated with theri body weight. There was no association of IGF-1 levels to hemoglobin, serum cholesterol, and cogntive function.
Conclusion: In this study of healthy older men and women, IGF-1 level was associated with there body weight. We could not find any association between IGF-1 levels and cogntive function.
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KEYWORD
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Insulin-like growth factor 1(IGF-1), Cognitive function, KDSQ, S-SDQ, MMSE
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